Roles for Non-coding RNAs in Spatial Genome Organization
نویسندگان
چکیده
منابع مشابه
Non-Coding RNAs as Regulators of Transcription and Genome Organization
“Junk DNA” was used as the provisional label for the portions of a genome for which no discernible function had been identified [1]. In a 1980 review in Nature Leslie Orgel and Francis Crick described junk DNA as having “little specificity and conveying little or no selective advantage to the organism” [2]. For decades, scientist considered the non-protein-coding portions of the genome as dispe...
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Non-coding RNAs are involved in a multitude of cellular processes but the biochemical function of many small non-coding RNAs remains unclear. The family of small non-coding Y RNAs is conserved in vertebrates and related RNAs are present in some prokaryotic species. Y RNAs are also homologous to the newly identified family of non-coding stem-bulge RNAs (sbRNAs) in nematodes, for which potential ...
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Protein-coding genes account for only a small fraction of the human genome and most of the genomic sequences are transcriptionally silent, but recent observations indicate significant functional elements, including non-coding protein transcripts in the human genome. Long non-coding RNAs (lncRNAs) have been defined as transcripts of >200 nucleotides without protein-coding capacity that perform t...
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ژورنال
عنوان ژورنال: Frontiers in Cell and Developmental Biology
سال: 2019
ISSN: 2296-634X
DOI: 10.3389/fcell.2019.00336